Potential Deficiencies in Alzheimer's

Published on 14 November 2023 at 19:07

Potential Deficiencies in Alzheimer's

—Jill Fandrich, PharmD, CRPh


Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects memory and cognitive function. While the exact cause is still largely unknown, researchers have identified several potential deficiencies that may play a role in the development and progression of Alzheimer's. It is important to note that these deficiencies are theoretical, and further research is needed to fully understand their significance.


1. Amyloid beta accumulation - One of the hallmark features of Alzheimer's is the accumulation of amyloid beta plaques in the brain. These plaques are believed to disrupt normal brain function and trigger a cascade of events leading to cognitive decline. The exact mechanism behind amyloid beta accumulation is still not fully understood. It is hypothesized that deficiencies in the clearance of amyloid beta or increased production may contribute to this process.


2. Tau protein dysfunction - Another key characteristic of Alzheimer's disease is the accumulation of abnormal tau protein tangles within neurons. Tau proteins normally help maintain the structural integrity of nerve cells, but in Alzheimer's, they become misfolded and clump together, disrupting cellular function. It is believed that deficiencies in the regulation of tau protein, including abnormal phosphorylation or impaired clearance mechanisms, may contribute to the formation of these tangles.


3. Neurotransmitter imbalance - Neurotransmitters, such as acetylcholine, serotonin, and glutamate, play crucial roles in neuronal communication and cognitive function. Studies have suggested that deficiencies in specific neurotransmitters, particularly acetylcholine, may contribute to the impairment of memory and cognitive abilities seen in Alzheimer's disease.


4. Oxidative stress - Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (free radicals) and the body's antioxidant defense mechanisms. It is thought that oxidative stress is involved in the onset and progression of Alzheimer's disease by causing cellular damage and promoting inflammation in the brain. Deficiencies in antioxidant systems or increased oxidative stress may contribute to the development of the disease.


5. Neuroinflammation - Chronic inflammation in the brain, known as neuroinflammation, has been linked to various neurodegenerative disorders, including Alzheimer's disease. It is believed that deficiencies in the regulation of the immune response in the brain or dysregulation of inflammatory processes may contribute to the progression of Alzheimer's pathology and neurodegeneration.


6. Mitochondrial dysfunction - Mitochondria are the powerhouses of cells responsible for generating energy. Dysfunction in these cellular structures has been implicated in a range of neurodegenerative diseases, including Alzheimer's. Deficiencies in mitochondrial function, such as impaired energy production or increased oxidative stress within these organelles, may contribute to neuronal damage and the progression of Alzheimer's pathology.


It is important to note that these deficiencies are not necessarily the direct cause of Alzheimer's disease but are potential contributing factors. Further research is needed to fully understand the complex interplay between these various mechanisms and to develop effective treatments for Alzheimer's.


Within the depths of Alzheimer's, where memories fade, and identities blur, lies the profound reminder that our minds possess fragile vulnerabilities. Yet, it is precisely in acknowledging these potential deficiencies that we uncover the untapped strength to cherish every memory and embrace the beauty of the present moment.

—Dr. Jill

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